What Customers Say
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MsXelerator:
Prof. Hans-Gert Janssen, Unilever R&D Vlaardingen B.V. Vlaardingen, the Netherlands
Using modern analytical techniques such as GC-(high resolution) MS, massive amounts of data can be recorded rapidly for large sets of even the most complex food or food flavor samples. The bottleneck nowadays is not the recording of the data: up to 50 samples can be analyzed on one day, reliably and with very high sensitivity and good repeatability and reproducibility. The difficult point is transforming the data into information and ultimately into knowledge and understanding.
MsXelerator is the tool we use to align and process high resolution GC-MS data sets for data evaluation using the integrated chemometrics methods, or for use with other software packages for data evaluation. MsXelerator is easy to operate. It follows a very logical workflow. Default settings are often spot on, and when necessary the user can easily fine-tune specific settings for a better performance for specific features. -
GC-Analyzer:
Timo Tolksdorf, Dipl.-Chem. material technique polymers – material-/emission-/failureanalysis Volkswagen AG, Wolfsburg, Germany
It is really incredible, what we are able to identify now. Substances, that are only used for surface treatment in low concentrations, or low level polymer additives can now be identified by measuring the complete material. Superposed substances can now be separated by their characteristic masses. In addition, the accuracy of found substances in screenings has greatly increased. -
GC-Analyzer:
Debra Blondell, GC/MS Specialist, Honeywell, Buffalo, USA
I have never been able to locate a component in one of our standards because it was co-eluting with another peak plus I was thinking that the ions were very similar which also prevented me from finding it. We could never acquire a standard of it either so spiking the standard with the component was out of the question. It went undetected.
GC-Analyzer was able to identify the peak. It does co-elute which I expected. I am so beyond excited. -
GC-Analyzer:
Cees Bijsterbosch, Specialist Organic Chemistry, Het Waterlaboratorium, Haarlem, The Netherlands
I analyze target and non-target compounds in surface and drinking water by GC-MS for over 20 years. The GC-Analyzer software is excellent in detecting and identifying compound levels lower than 10 ng/l in combination with our NIST library. Our screening analysis got a great boost through a simpler way of identifying compounds and reporting. Results are much faster available for our customers. -
‘MsXelerator is an essential tool nowadays in processing our proteomics datasets. It provides sensitive algorithms to search for mass spectral doublets, either targeting absolute mass differences (in the context of e.g. SILAC-based proteomics experiments or chemical modifications of amino acids) or relative mass differences. This latter feature is unique in its kind, as it allocates14N/15N-isotopically labeled peptides characterized by a relative mass difference of 1.2% of the m/z-value of the peptide and user-specified peak intensity ratios. All data processing is performed on the raw MS data, without any prior data conversion.
It is without any doubt that this application has boosted our Immuno Proteomics research. Moreover, the good hands-on training and the direct contact with the software developers of MsXelerator allows us to have user-defined modules integrated in the basic version of the application.’
Hugo D. Meiring, PhD, Senior Scientist Biomolecular Mass Spectrometry Institute for Translational Vaccinology, Intravacc. -
‘We really enjoy working with MsMetrix to implement MsXelerator software according to our needs.
Chenghong Zhang, Genentech / Roche, San Francisco, USA
The IPeaks module, for recognition of high resolution isotopic patterns is a very powerful tool to process our routine reactive metabolite trapping data.’ -
Miranda de Kok, PhD, Biomedical Analysis, Dept. of Pharmaceutical Sciences, Faculty of Science University Utrecht, the Netherlands‘We successfully used the Reference Peak Warping (RPW) function of the MsXelerator software to align profiles of rat-urinary metabolites obtained by capillary electrophoresis–mass spectrometry. The excellent alignment allowed reliable principal component analysis revealing significant differences between antibiotic-treated and non-treated rats.’
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‘At Evolva SA, we have been using MsXelerator with great success for more than 4 years. Finding unknown molecules in complex sample matrix requires challenging and extensive LC/MS data mining, without mentioning the time needed to review high throughput screening data. MsXelerator software and particularly the module MPeaks does a great job in deconvoluting and comparing MS chromatograms in order to find the small differences which are relevant for our applications. Moreover, the clever interactivity between MPeaks and MS-compare help us accelerating our analysis thanks to the multiple filters and statistical tools, all with great confidence. Beyond all doubt, MsXelerator is a powerful all-in-one software platform to process LC/MS data, removing the hassle of buying several expensive add-ons from the instrument vendors. I also particularly enjoy the collaboration, expertise and quick responsiveness of MsMetrix, regarding customization to our special requests! ’
Christophe Folly, Research Scientist, Evolva SA, Switzerland -
Dr. P.A. van Veelen, LUMC, Head Mass spectrometry group, Leiden, The Netherlands‘MsXelerator enabled us to select peptides from very complex mixtures by recognition of their specifically induced isotope pattern. Manual inspection of thousands of spectra has been replaced by an hour of analysis time using MsXelerator.’
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‘MsXelerator is a real time-saver when processing our discovery and (pre)clinical Met-ID experiments at MSD (Schering-Plough, Organon).’
- One workflow in a multi vendor ms lab.
- Searches for artificial isotope patterns at low level that worked (labeled compounds).
- Customization.
